Association of Birth Weight with Polymorphisms in the IGF2, H19 and IGF2R Genes
نویسندگان
چکیده
منابع مشابه
Epigenetic consequences of artificial reproductive technologies to the bovine imprinted genes SNRPN, H19/IGF2, and IGF2R
Animal breeders have made widespread use of assisted reproductive technologies to accelerate genetic improvement programs aimed at obtaining more, better and cheaper food products. Selection approaches have traditionally focused on Mendel's laws of inheritance using parental phenotypic characteristics and quantitative genetics approaches to choose the best parents for the next generation, regar...
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چکیده ندارد.
Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer
In different mammalian species, in vitro culture and manipulation can lead to aberrant fetal and peri-natal development. It has been postulated that these diverse abnormalities are caused by epigenetic alterations and that these could affect genes that are regulated by genomic imprinting. To explore this hypothesis relative to somatic cell nuclear transfer in sheep, we investigated whether the ...
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In most tissues IGF2 is expressed from the paternal allele while H19 is expressed from the maternal allele. We have previously shown that in some Wilms tumors the maternal IGF2 imprint is relaxed such that the gene is expressed biallelically. We have now investigated this subset of tumors further and found that biallelic expression of IGF2 was associated with undetectable or very low levels of ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2010
ISSN: 0031-3998
DOI: 10.1203/pdr.0b013e3181f1ca99